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| Product Name: |
High Quality Methotrexate with Good Price (CAS 59-
|
| Supply Ability: |
100g |
| Related proudcts |
api, pharmaceutical, intermediate, |
| Specifications |
medicine grade |
| Price Term: |
FOB,CNF,CIF |
| Port of loading: |
Shenzhen |
| Minimum Order |
100 |
| Unit Price: |
2.5 |
|
High Quality Methotrexate with Good Price
(CAS 59-05-2)
Quick ***ails:
Methotrexate CAS :Â 59-05-2 Brand: NEWBIO
MW: C20H22N8O5 MSDS: Avaiable
MF :Â 454.44 Sample: Avaiable
Category: Oncology drug Min order: 10grams
Quality standard:Â Â Â USPÂ Â Â EP Place of Origin:China
Introduction used as anti-tumour medicament.
Character Orange-yellow ,crystalline powder
Applications Pharmaceutical raw materials , Oncology drug
Product Description:
Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.
COA:
Text USP27 EP4 BP2002
Assay% 98.0-102.0 98.0-102.0 98.0-102.0
Residue on ignition% â‰?.1  Â
Specific roataion +19-+24 +19-+24 Â
Loss on drying% Â Â Â
Chromatographic purity% â‰?.0(total)  Â
 â‰?.5(individual)  Â
Water% �2.0 �3.0 �2.0
Organic Volatile impurites conforms
Sulphated ash%  �.1 �.1
Heavy metals ppm  50 1
Related substance   Â
Total  �.3 �.3%
Individual  At most five peaks At most five peaks
Impurity A%  �.5 �.5
Impurity B%  �.5 �.5
Impurity C%  �.5 �.5
Impurity D%  �.5 �.5
Impurity E%  �.5 �.5
Unknown Impurity %  �.5 �.5
(R)-Methotrexate%  �.0 �.0
FEATURED PRODUCT:
Wuhan Newbio Pharm-tech Co., Ltd.
S# CAS No. Product Name S# CAS No. Product Name
1Â 86639-52-3 7-Ethyl-10-Hydroxycamptothecin |
| Company: |
Wuhan Newbio Pharm-tech Co., Ltd.
|
| Contact: |
Mr. Jason Edwards |
| Address: |
858, East Lake, High-Tech Development Zone, Wuhan, Hubei, China |
| Postcode: |
430075 |
| Tel: |
+86-027-87002705 |
| Fax: |
86-27-87050469 |
| E-mail: |
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