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| Product Name: |
Hot Sell Small Molecular API Erlotinib (CAS# 18332
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| Supply Ability: |
100g |
| Related proudcts |
api, pharmaceutical, intermediate, |
| Specifications |
medicine grade |
| Price Term: |
FOB,CNF,CIF |
| Port of loading: |
Shenzhen |
| Minimum Order |
100 |
| Unit Price: |
2.5 |
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Hot Sell Small Molecular API Erlotinib
(CAS# 183321-74-6)
Chemical Information:
Product Name Erlotinib
Molecular Formula C22H23N3O4
Molecular Weight 393.44
Storage Store at -20°C
Targets EGFR
IC50 2 nM
Original Wuhan, China
Brand name NEWBIO
Purity 99%
Appearance White Powder
Package 100g/bag; 1KG/bag or as required
Shipping Fast and secure shipping by DHL,EMS,UPS, FedEx..
Shipping leading time Within 12 hours after receiving the payment
Payment Terms Western Union, Money Gram , T/T, Bitcon
MOQ 100g
Supply ability Mass stock
Description:
Erlotinib is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.
Application:
At doses of 100 mg/kg, Erlotinib HCl completely prevents EGF-induced autophosphorylation of EGFR in human HN5 tumors growing as xenografts in athymic mice and of the hepatic EGFR of the treated mice. Erlotinib HCl (100 mg/Kg) inhibits H460a and A549 tumor models with 71 and 93% inhibition rate.
Erlotinib inhibits purified EGFR tyrosine kinase and EGFR autophosphorylation intact cells with 50% inhibition concentration IC50 values of 2 nmol/L and 20 nmol/L respectively. Erlotinib competes for the ATP-binding sits on the intracellular domain of EGFR resulting in the inhibition of downstream signaling pathway involved in angiogenesis, cell propagation and cell survival. Erlotinib concentration-dependently inhibits EGFR-mediated propagation signals transduction, displays prominent anti-tumor activity against neoplasms harboring EGFR expression and exhibits a tolerable toxicologic profile.
FEATURED PRODUCT:
Wuhan Newbio Pharm-tech Co., Ltd.
S# CAS No. Product Name S# CAS No. Product Name
1 86639-52-3 7-Ethyl-10-Hydroxycamptothecin 25 183321-74-6 Erlotinib
2 154229-18-2 Abiraterone Acetate 26 183319-69-9 Erlotinib Hydrochloride
3 50-76-0 Actinomycin D 27 159351-69-6 Everolimus
4 106941-25-7 Adefovir 28 56296-78-7 Fluoxetine Hydrochloride
5 850140-72-6 Afatinib 29 184475-55-6 Gefi |
| Company: |
Wuhan Newbio Pharm-tech Co., Ltd.
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| Contact: |
Mr. Jason Edwards |
| Address: |
858, East Lake, High-Tech Development Zone, Wuhan, Hubei, China |
| Postcode: |
430075 |
| Tel: |
+86-027-87002705 |
| Fax: |
86-27-87050469 |
| E-mail: |
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