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| Product Name: |
Top Quality Small Molecular API Cediranib (CAS: 28
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| Supply Ability: |
100g |
| Related proudcts |
api, pharmaceutical, intermediate, |
| Specifications |
medicine grade |
| Price Term: |
FOB,CNF,CIF |
| Port of loading: |
Shenzhen |
| Minimum Order |
100 |
| Unit Price: |
2.5 |
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Top Quality Small Molecular API Cediranib
(CAS: 288383-20-0)
Chemical Information:
Product Name
Cediranib
Molecular Formula C25H27FN4O3
Molecular Weight 450.51
Storage Store at -20°CÂ
Targets VEGFR2/KDR c-Kit VEGFR3/FLT4 VEGFR1/FLT1 PDGFRβ
IC50 0.5 nM 2 nM � nM � nM   5 nM
Dosage
5 mg/kg
Â
Stability
3 years   - 20 ºC powder
6 months  -80 ºC dissolved in a solvent
Solubility Soluble in DMSO >Â 10 mM
General tips For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months.
Shipping Condition
Evaluation sample solution :Â ship with blue ice
All other available size: ship with RT , or blue ice upon request
***ails:
Synonyms:Cediranib;4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline;Cadiranib(AZD2171);Cediranib(AZD2171);AZD2171;Recentin;Cadiranib;Cediranib R
Â
Description:Cediranib is a highly potent inhibitor of VEGFR with IC50 value of <1 nM.
Application:
Cediranib inhibition of bFGF and EGF when an IC50 of 0.5 and 0.11 μM. In the MG63 cell lines, Cediranib inhibiting PDGF-AA, IC50 of 0.04 μM. Cediranib Flt-1 associated kinase inhibition, IC50 of 5 nM, Cediranib inhibition of VEGF-C and VEGF-D receptor Flt-4, IC50 of less than 3 nM. [1] In addition, cediranib inhibition of c-Kit and PDGFR-β tyrosine kinase, IC50 were 2 and 5 nM. In vitro, micromolar concentrations cediranib can directly inhibit the proliferation of tumor cells. Sub nanomolar Cediranib blocking tubules produced, and inhibits VEGF-induced angiogenesis in vivo. Â
COA:
Item SpecificationÂ
Specific rotation +39.5 to +41.5°Â
State of solution(transmittance) Clear 98.0% min.
Chloride[cl] 0.020% max.Â
Ammonium [NH4] 0.02% max.Â
Sulfate[SO4] 0.020% max
Iron[Fe] 10ppm max.
Heavy metals [Pb] 10ppm max
Arsenic[As2O3] 1ppm max
Other amino acids Chromatographically not ***ectable
Loss on drying 0.20% max.Â
Residue on ig |
| Company: |
Wuhan Newbio Pharm-tech Co., Ltd.
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| Contact: |
Mr. Jason Edwards |
| Address: |
858, East Lake, High-Tech Development Zone, Wuhan, Hubei, China |
| Postcode: |
430075 |
| Tel: |
+86-027-87002705 |
| Fax: |
86-27-87050469 |
| E-mail: |
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